Gel-forming mucins appeared early in metazoan evolution
نویسندگان
چکیده
منابع مشابه
Gel-forming mucins form distinct morphologic structures in airways.
Gel-forming mucins, the primary macromolecular components of airway mucus, facilitate airway clearance by mucociliary transport. In cystic fibrosis (CF) altered mucus properties impair mucociliary transport. Airways primarily secrete two closely related gel-forming mucins, MUC5B and MUC5AC. However, their morphologic structures and associations in airways that contain abundant submucosal glands...
متن کاملGel-forming mucins. Notions from in vitro studies.
Mucus secretions form a protective barrier in the mucosa of the auditory, gastrointestinal, respiratory, and urogenital systems, and the conjunctiva in the eyes. A family of glycoproteins known as gel forming mucins is the major component of the mucus. Gel-forming mucins are among the largest and most complex proteins known. Their polypeptide chains comprise thousands of amino acid residues org...
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متن کاملSubmaxillary mucins. Intermolecular interactions and gel-forming potential of concentrated solutions.
The intermolecular interactions in concentrated solutions of pig submaxillary mucin (PSM) and sheep submaxillary mucin (SSM) were studied by mechanical spectroscopy. PSM and SSM were purified from detectable protein and nucleic acid by equilibrium centrifugation in a CsCl density gradient. PSM and SSM isolated in the presence of proteinase inhibitors showed distinct differences from preparation...
متن کاملGel-forming and cell-associated mucins: preparation for structural and functional studies.
Secreted and transmembrane mucins are important components of innate defence at the body's mucosal surfaces. The secreted mucins are large, polymeric glycoproteins, which are largely responsible for the gel-like properties of mucus secretions. The cell-tethered mucins, however, are monomeric but are typically composed of two subunits, a larger extracellular subunit which is heavily glycosylated...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0705984104